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Article
November 15, 1947

CYSTIC FIBROSIS OF THE PANCREAS

JAMA. 1947;135(11):717-718. doi:10.1001/jama.1947.02890110035012
Abstract

Passini in 1919 was apparently the first to describe typical findings of cystic fibrosis of the pancreas in an infant who had had abnormal stools since birth and who died of bronchopneumonia at the age of 9 months. Severe respiratory infection in infants associated with a celiac-like picture was described by Garrod and Hurtley in 1913. Andersen1 in 1938 correlated the pancreatic changes with the development of steatorrhea and pneumonia and established cystic fibrosis of the pancreas as a definite clinical entity. She collected 27 cases from literature and 22 cases from records of necropsies at the Babies' Hospital in New York. Analysis of these cases revealed three distinct groups: 1. In 5 cases death occurred in the first week of life from some form of intestinal obstruction. In 2 cases the obstruction was due to so-called meconium ileus. 2. Nineteen infants died between the ages of 1 week

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