Studies during the past decade of the behavior of colloid systems such as proteins received a marked impetus from the contributions of Tiselius of Uppsala and Theorell in Stockholm. The manufacturing of apparatus based on the ideas of Tiselius made it possible to apply the microscopic method of electrophoretic analysis of serum to biological and medical problems. Thus it was found that in disease accompanied by fever and tissue destruction the concentration of the alpha globulin components is significantly increased and when an antigen-antibody system is involved the gamma globulin is found considerably elevated.
Krebs1 in 1946 reported the case of a 15-year-old white girl with hypoproteinemia due to malnutrition. Electrophoretic studies of her plasma demonstrated a diminished gamma globulin fraction, which increased when the patient was placed on a high protein diet Harris and Schick2 reported on a group of patients who had infections of the respiratory
AGAMMAGLOBULINEMIA. JAMA. 1954;156(11):1084-1085. doi:10.1001/jama.1954.02950110046016