Since chest pain is common in persons over 50 years of age, it is important to differentiate between that caused by coronary artery disease and that due to other causes. Certain differential criteria that have been emphasized in the past have been reexamined by various observers. Master and his associates1 studied a series of 200 consecutive patients with chest pain, half of whom had abnormalities in their resting electrocardiogram. Of this group most were men over 50. The other half showed no abnormalities in their electrocardiogram or in a standard exercise test. Most of these were neurotic, and in none had heart disease developed in a subsequent four year follow-up. Most of this group also were men, and nearly half of them were over 50.
CARDIAC AND NONCARDIAC CHEST PAIN. JAMA. 1954;156(11):1085. doi:10.1001/jama.1954.02950110047017