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November 25, 1950

Chemotherapie der Tuberkulose mit den Thiosemikarbazonen

JAMA. 1950;144(13):1137-1138. doi:10.1001/jama.1950.02920130089051

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This German volume is the result of studies initiated in the hope of establishing a chemotherapy for tuberculosis. Experimental tests were performed exactly and were intended to build a causal therapy for tuberculosis similar to those for other bacterial infections. With the basic acknowledgment of differences between animal experiments and the treatment of tuberculous man, it was recognized that if the semicarbazones, whose specific action was demonstrated in 1946, could affect a human type of tuberculous infection in the highly susceptible guinea pig, such materials in harmless doses might prove useful in the various forms of tuberculosis in man. While the action of streptomycin is conspicuous in guinea pig tuberculosis, paraaminosalicylic acid (PAS) is poorly tolerated by these animals and is not as acceptable as the semicarbazones, even though it is tolerated better in less susceptible species. Thus the possibility of a causal therapy of tuberculosis exists.

This volume consists

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