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Article
December 11, 1954

UTERINE FIBROIDS

JAMA. 1954;156(15):1404. doi:10.1001/jama.1954.02950150026009
Abstract

Uterine fibroids are said to be the commonest of all tumors. Kellar1 states that they are found in 25% of all women examined at autopsy, and Irwin2 says that 50% of all women over 50 years of age have them. Since they increase in size only during the years when a woman is menstruating, it is believed that they are in some way related to ovarian function, but the exact cause of these tumors is not known. Kellar found that 25% of those removed surgically were associated with endometriosis. In a series of 58 patients, Jones3 found multiple tumors in 42 and hyaline degeneration in 51. None of the patients in his series showed any evidence of malignant degeneration. Kellar states that sarcomatous changes occur in less than 1%, and Irwin found sarcoma in 0.3% of a series of 632. If sarcomatous degeneration does occur the chances

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