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To the Editor:—
I have read with considerable interest the comments by Dr. Carey P. McCord and Dr. Rutherford T. Johnstone in The Journal for Sept. 11, 1954, page 194, on my paper entitled "Aplastic Anemia Following Exposure to Carbon Tetrachloride" (J. A. M. A.155:737 [June 19] 1954). Both of your correspondents raise some question as to the relationship of the carbon tetrachloride and the observed bone marrow damage. I believe they are justified in regarding the causal association as unproved. Indeed, the tentative nature of my conclusions would negate the imputed "diagnostic finality" of the paper. The three cases cited hardly represent a controlled experiment, and confirmation is needed. It is significant that, in the cases reported, the first patient also had severe, overt damage to the liver from which recovery took place and the second patient showed some damage to the liver on postmortem examination. Careful
Straus B. APLASTIC ANEMIA AND CARBON TETRACHLORIDE. JAMA. 1954;156(15):1428. doi:10.1001/jama.1954.02950150050025