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February 28, 1948


Author Affiliations

Fulham Road, London S.W. 3.

Manchester 20, England.

JAMA. 1948;136(9):643-644. doi:10.1001/jama.1948.02890260051022

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To the Editor:—  According to J. J. Webster (The Journal, Dec. 6, 1947, p. 901) available reports on the subject of urethane in leukemia "are chiefly in the British and German journals, and represent an optimistic view as to the future of urethane therapy." As far as the original paper was concerned (Paterson, E.; Ap Thomas, I.; Haddow, A., and Watkinson, J. M.: Lancet1:677, 1946), it was certainly not our intention to create any impression of optimism, and we do not consider that such could in fact have been conveyed to the majority of readers. While the palliative effects of urethane were recognized as remarkably similar to those obtained by standard methods of high voltage roentgen therapy, it was on the contrary made clear that no indication had been found "that permanent benefit may result from the use of urethane in either myeloid or lymphatic leukaemia." This goes considerably

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