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Article
March 13, 1948

STATISTICAL STUDY OF LIFE CYCLE OF 1,154 CASES OF DUODENAL ULCER

JAMA. 1948;136(11):736-739. doi:10.1001/jama.1948.02890280004002
Abstract

Attention has frequently been focused on many phases of peptic ulcer. Although most factors in the production and life cycle of peptic ulcer are probably known, the complete picture of this condition has not been fully attained. The causes of peptic ulceration remain a debatable question. The role of acid still seems predominant in the etiology of this condition. The importance of psychogenic influences is fairly well established, but the exact mechanism in which it plays in the etiology of peptic ulcer is hot definitely known. There is no doubt of its constant association in the majority of cases of duodenal ulcer.

The life cycle of duodenal ulcer usually follows a distinct clinical pattern. In many instances there are clinical variables. The clinical variations are due to the type, acute or chronic, healing, recurrences and complications. The majority of duodenal ulcers are of the chronic type. The symptoms often come

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