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This is a well coordinated summary of developments in our knowledge of the sex hormones derived from the study of the pituitary, gonads and adrenals in animals. It shows an appreciation of the varying factors which must be taken into account when discussing any reaction. For example, in Part I, on the subject of gonadotropins, there is a chapter devoted to factors which influence the gonadotropic activity of the pituitary, another on factors which influence the reaction of the gonads to gonadotropins and another on factors which affect the cytologic structure and weight of the anterior lobe of the pituitary. The section on androgens has a chapter dealing with the action of these hormones on the reproductive system before complete differentiation and another chapter on their action after complete differentiation. The section on estrogens is treated in the same manner. The author states that his leading motive is the ultimate
Biological Actions of Sex Hormones. JAMA. 1948;136(11):806. doi:10.1001/jama.1948.02890280074033