World War II caused disruption of research on leprosy, and took essential personnel but did not stop progress. The most outstanding advancement in leprosy was made in clinical treatment. In 3 cases reported in a review by Dr. James A. Doull1 successful surgical removal was apparently made of the primary lesion. In 2 cases evidence of dissemination of the disease had not appeared eleven years postoperatively. In the third case, that of a patient operated on in 1916, evidence of leprosy had not appeared on reexamination in 1944, twenty-eight years after excision of the original lesion. Use of diphtheria toxoid was considered to have failed to show beneficial results in treatment. This was equally true of transfusions of pooled blood plasma. Calcium gluconate was reported to give beneficial results when administered intravenously in cases of painful neuritis.
Preliminary reports of treatment with streptomycin were inconclusive. Many toxic manifestations were
LEPROSY. JAMA. 1948;136(12):830-831. doi:10.1001/jama.1948.02890290020007