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Professor Cicardo's monograph on the biologic importance of potassium is the most exhaustive written on this subject, as the 774 references discussed in the text testify. The book comprises sixteen chapters: 1, the origin and significance of potassium; 2, intracellular potassium; 3, potassium in the tissues: 4, extracellular potassium; 5. toxicity; 6, striated muscle and potassium; 7, cardiac muscle; 8, smooth muscle; 9, nerve; 10, central nervous system: 11, digestive secretions; 12, adrenals; 13, other glands of internal secretion: 14, shock; 15, anoxia, acid-base equilibrium, and 16, potassium in various pathologic conditions. On each of these subjects the author reviews the literature and presents the conclusions derived therefrom as well as from his own work.
Professor Cicardo's own work, presentedin detail, was done mostly on frogs and includes cellular permeability to potassium and the influence of ions, specially of calcium; the influence of potassium on muscular contractions: the relation between
Importancia biológica del potasio. JAMA. 1948;136(12):848. doi:10.1001/jama.1948.02890290038021