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April 10, 1948

Contribuição para o estudo hematológico e clinico da anemia perniciosa (moléstia de Addison-Biermer)

JAMA. 1948;136(15):1007. doi:10.1001/jama.1948.02890320051025

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The greatest value of this monograph on pernicious anemia lies in the completeness with which the author has reviewed the present knowledge of the subject. The bibliography is remarkably complete and will be of value to all workers in the field. The monograph opens with a detailed consideration of the pathogenetic mechanisms of anemia and a suggested new classification which seems to offer no advantages over the. etiologic classification already in use for many years. Important stress, however, is laid on the constitutional and nutritive aspects of the etiology of pernicious anemia. The author has suggested subdivisions of the disease according to the predominance of anemic, gastrointestinal or neurologic symptoms and signs This emphasis seems unwarranted except to draw attention to the occasional case of combined system disease with little or no anemia. Studies of the urine of normal and pernicious anemia patients for antianemic activity were negative. The evidences

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