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April 10, 1948

La pathogénie des altérations électrocardiographiques de la péricardite: Etude clinique et expérimentale

JAMA. 1948;136(15):1007. doi:10.1001/jama.1948.02890320051027

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This monograph is based on the experience of the author with 138 cases of acute and chronic pericarditis (constrictive and nonconstrictive) of various etiology. It excludes the pericarditis associated with stenocardia. It analyzes the electrocardiographic data before and after operation. In 6 cases histologic examination of the myocardium was made at necropsy. The author refers to but does not document his results with experimental pericarditis, local and generalized, in dogs and monkeys. On the basis of these observations the author concludes that the mechanism for the electrocardiographic alterations is due to bioelectrical changes in the epicardium. In the 6 cases examined by the author he found no evidence of histologic changes in the subepicardial myocardium. He reports that in animals injury within the myocardium does not cause changes in the electrocardiogram, whereas injury at the surface does. It is well known, as the author found, that myocardial damage not surfacing

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