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February 19, 1955


Author Affiliations

Maimonides Hospital of Brooklyn 4802 Tenth Ave. Brooklyn 19, N. Y.

JAMA. 1955;157(8):680. doi:10.1001/jama.1955.02950250054022

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To the Editor:—  The paper entitled "Triethylene Melamine in Bronchogenic Carcinoma with Vena Caval Obstruction" by Saline and Baum, which appeared in The Journal of Dec. 18, 1954, page 1493, has come to our attention. It seems to us that this article is too enthusiastic and does not recommend the precautions that must be used when giving triethylene melamine. It is well known that, owing to individual patients' tolerance, a daily dose of 5 mg. of triethylene melamine for four days may cause severe toxic reactions with suppression of the marrow in some patients. The case reports are such that we do not feel that conclusions can be drawn from them about the effectiveness of triethylene melamine.In case 1, the patient received numerous courses of nitrogen mustard and radiotherapy and in between these treatments received some therapy with triethylene melamine. To infer that this patient was benefited by triethylene

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