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April 17, 1948

Current Comment

JAMA. 1948;136(16):1051. doi:10.1001/jama.1948.02890330041014

HEMOCONCENTRATION AND GASTRIC ULCER  Hemoconcentration following extensive superficial burns was believed by Kapsinow1 to be the etiologic factor in the production of gastric and duodenal lesions (Curling's ulcer). Friesen and Wangensteen2 of the Department of Surgery, University of Minnesota Medical School, studied the question by experiments on dogs under deep intravenous sodium pentobarbital anesthesia (15 mg. per pound). In 12 of 14 dogs subjected to burns accompanied by the administration of histamine hemoconcentration developed, the hematocrit reading rising from an average of 44 per cent to an average of 55.7 per cent. Readings as high as 65 to 72 per cent were recorded in certain dogs. All 12 dogs showed congestion of the mucous membrane of the stomach and duodenum. Nine of them showed definite Curling's

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