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Article
April 17, 1948

RECENT ADVANCES IN TREATMENT OF PULMONARY DISEASE-Reply

JAMA. 1948;136(16):1062. doi:10.1001/jama.1948.02890330052023

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Abstract

The statement about the gratifying experience of "the most experienced men" is correct but my critic fails to appreciate the significance and the emphasis on the phrase "the most experienced men." Perhaps these men were overoptimistic, I am not sure! At any rate, even though experience with streptomycin was admittedly limited and more time was sorely needed for adequate appraisal of its possible good effects as well as its possible bad effects, five things seemed clear as of June 1947: 1. Streptomycin had a remarkable restraining influence on the growth of the tubercle bacillus in culture. 2. It had an astonishingly beneficial influence on tuberculosis in the experimental animal. 3. It had apparently a remarkably beneficial effect on the acute exudative lesions of tuberculosis infection in man. 4. In dosage then prevailing, it frequently damaged the vestibular nerve. 5. After some weeks of its use against human tuberculosis, the organism

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