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To the Editor:—
The editorial entitled "More About Vagotomy" on page 255 of the January 24 issue of THE JOURNAL states, "There is also a definite effect on the secretion, in most instances shown by histamine achlorhydria." The writer undoubtedly meant to say "insulin achlorhydria." All the evidence clearly shows that the hydrochloric acid secretion produced by histamine stimulation is not abolished by vagotomy. The insulin test of gastric secretion is generally recognized as a reliable means of determining whether the vagotomy has been complete, so that it is quite probable that the writer had this test in mind when he wrote the statement quoted.
The statement that "there is also a definite effect on the secretion, in most instances shown by histamine achlorhydria" was unfortunately an error. There appears to be no abolition of secretion after a perfect vagotomy. What is abolished is the cephalic phase of the
KESILMAN M. MORE ABOUT VAGOTOMY. JAMA. 1948;137(2):211. doi:10.1001/jama.1948.02890360093020