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March 12, 1955

A Ciba Foundation Symposium: The Chemical Structure of Proteins

JAMA. 1955;157(11):976. doi:10.1001/jama.1955.02950280100048

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This volume includes 16 papers given by specialists from Great Britain, France, Germany, and the United States. The papers deal chiefly with the isolation of pure proteins and peptides, the characterization of end-groups, and the specific splitting of particular bonds. Methods discussed for the determination of purity of proteins and peptides include countercurrent distribution and partition and ion-exchange chromatography. The procedures included for end-group determination are the methods of Sanger, the reaction with phenylisocyanate, the reduction of esters with lithium borohydride and lithium aluminum hydride, and the enzymatic splitting with amino- and carboxy-peptidases. Methods for specific bond splitting include the preparation of phenylthiohydantoins and certain enzymatic degradations. A number of chapters discuss the structure of specific proteins. The volume makes excellent reading for any person interested in protein chemistry. The subjects are presented clearly, and the discussions following the papers are very helpful. The book contains a short subject index.

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