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June 19, 1948


JAMA. 1948;137(8):702. doi:10.1001/jama.1948.02890420036009

Until recently the fact that an adequate dietary intake of protein is essential for normal formation of hemoglobin has been assumed without definite proof. The basis for such an assumption is, of course, the fact that hemoglobin is a protein and hence must be ultimately derived from the protein of the diet. This logical conclusion has been established with some difficulty, however, because of the interconvertibility of the various body proteins and because formation of hemoglobin has a "high priority" for any protein available for metabolism. lather prolonged and drastic dietary restriction of protein is therefore necessary before formation of hemoglobin is decreased and a demonstrable anemia results. This fact has been clearly demonstrated by Whipple and his collaborators in the dog and by several investigators in the rat.2 As an extension of this thesis Wayne University investigators have obtained evidence that not only the quantity but also the

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