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The monograph reports a follow-up study of 381 cases of infantile eczema compared with 454 noneczematous controls. Special attention is given to heredity and nutrition in the causation of the disease and to its prognosis with respect to allergic manifestations such as seasonal rhinitis, bronchial asthma, urticaria, papular urticaria (strophulus) and angioneurotic edema. All patients had been seen in pediatric wards or clinics during the first two years of life; the interval between first and last observation varied from a minimum of seventeen years to a maximum of thirty-eight years. Allergic diseases were commoner in parents and siblings of eczematous children than in those of controls, but the presence of environmental factors prevented definite conclusions about the mechanism of inheritance. Infantile eczema occurred more frequently in boys than in girls. The average age of onset was 5 months. The initial lesion healed at an average age of 2 years, but
Prognose und Erblichkeitsmomente bei Ekzema infantum: Eine klinisch-statistische Untersuchung von Allergieerscheinungen. JAMA. 1948;137(8):754. doi:10.1001/jama.1948.02890420088026