[Skip to Content]
[Skip to Content Landing]
Article
April 23, 1955

THERAPY OF VIRILIZING ADRENAL HYPERPLASIA WITH HYDROCORTISONE ACETATESUCCESSFUL THERAPY WITH INFREQUENT INTRAMUSCULAR INJECTIONS

Author Affiliations

New Orleans

From the Department of Medicine, Tulane University School of Medicine, and the Endocrine Research Laboratory of the Alton Ochsner Medical Foundation.

JAMA. 1955;157(17):1479-1481. doi:10.1001/jama.1955.02950340009003
Abstract

The use of cortisone therapy of adrenal hyperplasia with virilism, as introduced by Wilkins in 1950,1 is one of the most gratifying experiences in medicine. It enables one to convert a virilized, amenorrheic, sterile woman into a woman potentially capable of conception. Prior to the present, the best therapy available appeared to be the intramuscular injection of cortisone acetate two or three times a week.2 We are not aware of anyone who has successfully spaced injections with the currently available preparations of cortisone acetate at intervals greater than four days. Prader3 used macrocrystalline cortisone in dosages of 800 mg. every 30 days with good results. Somewhat larger doses are required orally and must be given in divided doses three or four times daily. In general, oral therapy has been found by various groups to be less effective than intramuscular therapy.4 In addition, as pointed out by

First Page Preview View Large
First page PDF preview
First page PDF preview
×