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Article
July 17, 1948

MANAGEMENT OF GASTRIC HEMORRHAGE USING TOPICAL THROMBIN

Author Affiliations

Sterling, Colo.

JAMA. 1948;137(12):1035-1036. doi:10.1001/jama.1948.82890460001006
Abstract

The most common complication of peptic ulcer is hemorrhage. In persons over 40, because of the rigidity of the arterial walls, severe bleeding is more common. The mortality in this age group is eight times that of those under 40. The mortality of those whose hemoglobin is below 9.4 Gm. (60 per cent) is four times that of those whose hemoglobin is above 60 per cent.1

Thrombin is a sterile, standardized, hemostatic powder obtained from bovine plasma, and was originally intended to contract capillary bleeding either as a dry powder or in sterile isotonic solution. Its action depends on its ability to clot fibrinogen, thus forming a natural clot which seals the capillary ends. It is supplied in sterile packages of ampules containing 5,000 Iowa units.2

REPORT OF CASES 

CASE 1.—  On March 15, 1947, at about 3 a.m., A.J., a business man aged 64, was found in a

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