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July 24, 1948


JAMA. 1948;137(13):1150-1151. doi:10.1001/jama.1948.02890470050021

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To the Editor:—  In the January 3 issue of The Journal, page 8, appeared an article by Zeller, Hirsh, Sweet and Dowling entitled "Treatment of Meningitis with Sulfadiazine and Sulfamerazine," in which the results of therapy with a combination of sulfadiazine and sulfamerazine in 75 cases of meningococcic meningitis are compared statistically with the results achieved against this disease in previous studies using either sulfadiazine or sulfamerazine alone. Unfortunately, the authors arrive at conclusions which are not supported by their own results but are based on the fallacious interpretation of statistical data.Dr. Dowling began therapy with the sulfadiazine-sulfamerazine combination following my suggestion at the occasion of his personal visit to my laboratory in the fall of 1944. However, he and his co-workers arbitrarily increased the dosage of the combination "25 to 33 per cent" above the generally accepted routine dosage of sulfonamide drugs. Thus, adult patients received 8 to

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