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July 31, 1948

Studies on the Formation of Cellular Substances During Blood Cell Production

JAMA. 1948;137(14):1265. doi:10.1001/jama.1948.02890480085039

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During the last two decades, remarkable progress in hematology has been achieved by means of sharper demarcation of the various clinical pictures and by application of dynamic physiologic mechanisms to the interpretation of the presenting symptoms and signs. However, in most of the disorders full comprehension is lacking because the underlying disturbances of cellular metabolism remain an enigma. In this important monograph, Thorell has applied the ingenious technics developed by Caspersson for the study of cellular protein formation to the problems of blood cell production. The complicated microspectrographic methods used in these investigations are described in detail. By comparison of the distribution and concentration of the ribose polynucleotides in the hemopoietic cells with the quantitative cytology of the bone marrow, it could be shown that the new formation of cellular proteins during hemopoiesis takes place at an early stage of development. During this stage, high concentrations of ribose polynucleotides exist

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