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September 11, 1948


Author Affiliations

New York

From the Division of Pharmacology and Chemotherapy, Warner Institute for Therapeutic Research, and the Medical Department, William R. Warner & Co., Inc.

JAMA. 1948;138(2):115-117. doi:10.1001/jama.1948.02900020011003

The development of a simple and efficient method for maintaining and prolonging an effective plasma level of penicillin and for reducing thereby the number of intramuscular or subcutaneous injections necessary has been the subject of various investigations during the last few years. In all instances, it was attempted to slow the absorption of the penicillin from the site of injection by incorporating the antibiotic either into a mixture of wax and oil1 or into water in oil emulsions2 or into an oily vehicle3 or into complex vehicles containing vasoconstricting agents.4 The greatest success in this respect has been attained by the penicillinwax-oil mixture of Romansky. However, the high melting point and the considerable viscosity of this preparation require special syringes, and the occasional occurrence of painful indurations and abscesses at the site of the injection is an undesirable complication.

An injectable preparation of penicillin, which can

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