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September 18, 1948


Author Affiliations

Ann Arbor, Mich.

From the Department of Biological Chemistry, Medical School, University of Michigan.

JAMA. 1948;138(3):207-213. doi:10.1001/jama.1948.62900030013008

The term protein was suggested by the Dutch chemist Mulder in 1839 as a designation for the universal component of tissues, both plant and animal. Protein was characterized by him as "unquestionably the most important of all known substances in the organic kingdom. Without it no life appears possible on our planet. Through its means the chief phenomena of life are produced."1 Today, more than a century after Mulder, the proteins are still "first" (Greek, prōteios) in the regulation of vital processes, and disturbances in their metabolism are associated with nutritive failure and with many pathologic conditions with which the physician is confronted.

Proteins are normal constituents of all animal cells and body fluids with the exception of the bile and the urine. They are essential components of both the protoplasm and the nucleus of the cell; hence they exert a profound influence on growth. They are important in

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