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October 2, 1948


Author Affiliations


From the Department of Clinical Science, University of Illinois Medical School (Dr. Krasno), the Division of Medicine, Northwestern University Medical School (Dr. Rhoads), and the Division of Surgery, Northwestern University Medical School, Department of Anesthesiology, Wesley Memorial Hospital, and Passavant Memorial Hospital (Dr. Karp).

JAMA. 1948;138(5):344-348. doi:10.1001/jama.1948.02900050012004

The preliminary results obtained with the inhalation of penicillin dust indicate that this is an effective and practical method in the treatment of many types of infections of the respiratory tract.1 The present report is a more extensive study of this procedure carried out on 357 patients from October, 1946.2 In this study more inclusive information has been obtained on the following aspects of the problem: the incidence and nature of allergic reactions occurring with the method, an evaluation of the efficiency of this method in a large number of patients, particularly those with bronchiectasis, and a further refinement of the method to increase its practicality for home, office and hospital use.

APPARATUS  The apparatus devised for this purpose delivers a fine nonirritating penicillin dust to the respiratory tract. It is simple mechanically and therefore lends itself to immediate use, when such treatment is indicated, in the hospital,

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