My colleagues and I, in common with all others dealing with diabetes, have long been disturbed by the increasing incidence of severe degenerative lesions in our patients. It appeared to us that data obtainable thus far from human beings were unsatisfactory as an aid in solving this problem, because of the impossibility of keeping such patients under sufficiently controlled conditions for sufficiently long periods of time. It seemed a reasonable expectation that if we could collect a series of diabetic animals and maintain them with known amounts of glycosuria for years, perhaps for the duration of their lives, observing the changes in the blood and tissues from time to time, we might gain more information about the mechanism by which the degenerative lesions occur than has been possible in studies of clinical material.
We have proposed, and indeed have begun, to render a good many dogs diabetic with alloxan, perhaps
RICKETTS HT. INSULIN AND DIET. JAMA. 1948;138(5):353-356. doi:10.1001/jama.1948.02900050021007