One cause of fever of obscure origin may be ectodermal dysplasia of the anhidrotic type. The absence of sweat glands and other characteristic features may be easily overlooked. In the case presented, as in similar cases, many months elapsed before the diagnosis became apparent.
REPORT OF A CASE
A white male infant, aged 11 months, was brought to the Monroe Clinic on Feb. 24, 1954, because of bouts of unexplained fever since birth. The history revealed that the child had been delivered by cesarean section during the eighth month of the mother's pregnancy. This delivery was performed because of the development of an obstetric complication, the exact nature of which is not known. The infant weighed approximately 6 lb. (2,721.55 gm.) at birth. Shortly after birth the child developed a skin rash and was described as being a feeding problem. It was then noticed that the child began to run
Stiles FC, Weir JR. ECTODERMAL DYSPLASIA PRESENTING AS FEVER OF UNKNOWN ORIGIN. JAMA. 1955;158(16):1432–1433. doi:10.1001/jama.1955.02960160026007b