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Article
October 23, 1948

ENTEROGASTRONE IN THE TREATMENT OF PATIENTS WITH DUODENAL ULCER

Author Affiliations

Detroit

From the Division of Internal Medicine, Harper Hospital, and from the Department of Gastroenterology, North End (Community Chest) Clinic, Detroit.

JAMA. 1948;138(8):552-557. doi:10.1001/jama.1948.02900080010003
Abstract

Greengard, Atkinson, Grossman and Ivy1 reported encouraging clinical results in the care of 58 patients with proved peptic ulcer by the parenteral administration of an enterogastrone preparation, an extract prepared from the mucosa of the small bowel of hogs. Their results indicate that most of their patients who failed to respond to the usual conservative regimen became symptom free during enterogastrone therapy and that enterogastrone therapy is effective not only in preventing recurrences during the period of its administration but in preventing recurrent ulcer attacks for a period of time after treatment is discontinued. These encouraging clinical results prompted this study.

PREVIOUS STUDIES WITH ENTEROGASTRONE  In 1930, Kosaka and Lim2 reported that an extract prepared from mucosa of both the small and large intestine of dogs inhibits gastric secretion. They named the active principle enterogastrone (derived from entero/n, gastr/on, chalone/one). In 1937, Gray," Bradley and Ivy3 prepared

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