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August 20, 1955


Author Affiliations

2314 Auburn Ave. Cincinnati 19.

JAMA. 1955;158(16):1461. doi:10.1001/jama.1955.02960160055016

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To the Editor:—  An already overburdened glossary provokes misgivings in anyone who proposes to coin a new term. There are occasions, however, when new experience calls for a word to encompass it. Recent clinical use of chlorpromazine and the Rauwolfia fractions has demonstrated that these new compounds are capable of producing amelioration of a wide spectrum of symptoms in psychiatric disorders on occasion and thus "normalizing" such patients. Recently another drug having limited therapeutic qualities of this general type has been reported by me (Science121:208 [Feb. 11] 1955, and Neurology5:319 [May] 1955) and is undergoing further study. Alpha (4-piperidyl) benzhydrol hydrochloride, or Frenquel, is effective in the prevention and treatment of model psychoses produced by hallucinogenic drugs such as lysergic acid diethylamide and mescaline, as well as in some clinical cases of dissociation syndromes of schizophrenic pattern. Although the neurophysiological, neurochemical, and neuropharmacological mechanisms behind the

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