This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
This is a report of a study among contact children in Brazil concerning the tuberculin reaction. The study is based on the findings of Willis and Saenz, who concluded that in the guinea pig the tuberculin reaction based on the persistence of the allergic state could be remobilized by the inoculation of tubercle bacilli—a condition termed by Willis as "latent" allergy. Saye and Assis verified this with BCG following primary vaccination in children and the anallergic state reactivated by revaccination. Assis in children and Rosenberg in adults noted the effect of tuberculin injections in reactivation. This was called "alergia infra-tuberculinica" by Assis (infratuberculin allergy). Braga studied 134 children and found that 107 (79.85 per cent) had positive reaction to tuberculin, while 27 (20.14 per cent) had negative. The 27 with negative reaction were studied as having infratuberculin allergy by administration of 0.1 mg. dead BCG intradermally; and, of these, 22
Contribuiçāo ao estudo da alergia infratuberculínica na infância. JAMA. 1948;138(10):785. doi:10.1001/jama.1948.02900100065029