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This Week in JAMA
July 14, 1999

This Week in JAMA

JAMA. 1999;282(2):107. doi:10.1001/jama.282.2.107

Annual influenza immunization is not routinely recommended for healthy adults younger than 65 years, but in addition to individual medical risks, the number of days lost from work and use of health care resources associated with influenza infection are substantial. Nichol and colleagues reportArticle that severe febrile illnesses and febrile upper respiratory tract illnesses, work absenteeism, health care visits, and medication use were reduced during the 1997-1998 influenza season in healthy adults who received intranasal trivalent, live, attenuated influenza virus vaccine compared with subjects who received placebo. In an editorialArticle, Poland and Couch point out that the effectiveness of inactivated influenza vaccine is similar to that of the live, attenuated intranasal vaccine, but the intranasal vaccine may offer several advantages, including self-administration.

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