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Article
December 4, 1948

DDT TOXICITY

JAMA. 1948;138(14):1043. doi:10.1001/jama.1948.02900140035011
Abstract

In animals the toxicity of ingested substances frequently depends on the composition of the concurrent diet. Thus a diet high in protein has been found to protect animals against such toxic agents as arsphenamine, chloroform and selenized wheat.1 Dietary fats augment the toxicity of chloronitrobenzene and dinitrotoluene.2

The widespread use of DDT (dichlorodiphenyltrichloroethane) as an insecticide has thus led Sauberlich and Baumann,3 of the College of Agriculture, University of Wisconsin, to study the effects of proteins and fats on the toxicity of ingested DDT. In preliminary tests, DDT was incorporated in their routine laboratory diet and fed to young mice and rats in graded concentrations ranging from 0.01 to 0.15 per cent. At a concentration of 0.01 per cent, the mice survived for nine weeks. At 0.05 per cent, they died within two weeks. At intermediate concentrations (e. g., 0.03 to 0.04 per cent) half of the

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