In 1943 the Council of the American Diabetes Association appointed the Committee for Standardization of the Insulin Syringe. The need for this action by the Council arose from the following facts. After the discovery of insulin in 1921, and its use by the profession in the treatment of diabetes became general in 1923, many different types of syringes for the administration of insulin gradually appeared on the market. Each of these syringes was considered by the originator of each of the various designs to have certain advantages over any of those previously available. The number of different types increased until literally dozens of different models were being manufactured.
In general, the different syringes were of two types— those which carried graduations indicating various fractions of a cubic centimeter and those which carried graduations indicating the number of units.
Early in its history insulin was marketed in dilutions as low as
PALMER LJ, PECK FB. OFFICIAL SYRINGE OF THE AMERICAN DIABETES ASSOCIATION. JAMA. 1949;139(1):7-9. doi:10.1001/jama.1949.02900180009002