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November 5, 1955

The Pathogenesis of Poliomyelitis

JAMA. 1955;159(10):1073. doi:10.1001/jama.1955.02960270093033

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This slender volume brings together the results of Dr. Faber's laboratory and clinical investigations of the pathogenesis of poliomyelitis that have been appearing in scientific journals over a period of many years. The book discusses its subject broadly enough to bring out the relationships of the epidemiology, symptoms, and immunology of the disease to its pathogenesis. The author's conclusions are in sharp contrast to the recently enunciated theories of pathogenesis of poliomyelitis that hold that the virus proliferates in and invades through the intestinal mucosa followed by a viremia and invasion of the central nervous system by way of the blood stream. Dr. Faber presents data indicating that the primary point of entry of virus is by the nerves of the oropharynx and perhaps the intestinal tract, following which the virus spreads to regional peripheral ganglia. He accepts the fact that viremia occurs but believes that his experimental data indicate

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