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Article
January 15, 1949

COMBINED STERPTOMYCIN-POTASSIUM IODIDE THERAPY

JAMA. 1949;139(3):158. doi:10.1001/jama.1949.02900200028014
Abstract

Iodides cause tubercle bacilli to appear in the sputum of patients with pulmonary tuberculosis. Jobling and Petersen1 showed that iodine neutralizes the fermentinhibiting properties of unsaturated fatty acids in caseous materials, thus releasing fermentation or autolysis. This causes a liberation of the bacilli and their appearance in the sputum. Jobling thought that the same autolytic process might serve a useful purpose by facilitating solution and absorption of caseous matter in other parts of the body and might thus expose masked tubercle bacilli to the influence of chemotherapeutic agents.

In the light of this significant suggestion and in view of the relatively poor results obtained in the treatment of fibrocaseous tuberculosis with streptomycin alone,2 Woody and Avery3 of the Department of Pathology, Vanderbilt University, tested the combined effect of potassium iodide and streptomycin against established tuberculosis in guinea pigs.

Forty-six young guinea pigs ranging in weight from 350

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