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December 17, 1955


Author Affiliations

Miami, Fla.

JAMA. 1955;159(16):1527-1529. doi:10.1001/jama.1955.02960330027009

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The purpose of this communication is to report the unusually prolonged survival time in several cases of adrenal cortical hypofunction (Addison's disease). Eight have survived from 15 to 18 years. The cases here reported fall into two categories. 1. In three early cases, recorded in 1940, the patients survived 15 years or more. Judged by present-day standards, their treatment may be regarded as inadequate in several respects, though in two of the three cases Swingle's cortical extract (noncommercial adrenal cortical hormone with a daily increment of sodium as chloride citrate and bicarbonate) and adequate sodium were used after 1933. 2. In eight consecutive cases of adrenal cortical hypofunction, the patients were placed on a regimen of Swingle's cortical extract between 1933 and 1940. Their treatment, I believe, has been adequate and highly satisfactory. Since all the cases have been previously reported in considerable detail, only thumbnail sketches are presented here.

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