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Article
January 21, 1956

TREATMENT OF MYASTHENIA GRAVIS WITH MESTINON BROMIDE

Author Affiliations

Indianapolis

From the Department of Neurology, Indiana University Medical Center.

JAMA. 1956;160(3):156-158. doi:10.1001/jama.1956.02960380004002
Abstract

• The diagnosis of myasthenia gravis was made in 165 patients whose symptoms were either aggravated by one-tenth of the minimal curarizing dose of tubocurarine chloride or objectively improved by intravenously administered neostigmine. Most patients satisfied both criteria. Mestinon was compared with neostigmine in these patients. Mestinon was effective in controlling the myasthenic symptoms, particularly the dysphagia. Its action was smoother because more prolonged, and no distressing sideeffects were observed even in patients who used it as long as 17 months.

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