Acetazolamide (Diamox) is widely employed as a diuretic agent. Although it contains a sulfonamide moiety, it differs chemically from all the bacteriostatic sulfonamides in that it does not have a benzene ring. Few side-effects or toxic manifestations have attended its use, but Pearson, Binder, and Neber recently reported a case of agranulocytosis attributable to this drug, and Moseley and Baroody described a hypersensitivity type of reaction to acetazolamide in a patient with known sensitivity to sulfonamide drugs. The nephrotoxic effects of the antibacterial sulfonamides are well known. However, the development of structural renal lesions following administration of acetazolamide has not been noted either in man or in the experimental animal.
The present report describes the occurrence of a nephrotic and hypersensitivity type of renal lesion in a patient who had received acetazolamide. Although the lesions observed were identical with those produced by bacteriostatic sulfonamides, clinical manifestations of renal damage did
Glushien AS, Fisher ER. RENAL LESIONS OF SULFONAMIDE TYPE AFTER TREATMENT WITH ACETAZOLAMIDE (DIAMOX). JAMA. 1956;160(3):204–206. doi:10.1001/jama.1956.02960380052012