• Prednisone was compared with cortisone as to potency and side-effects in 80 patients with allergic disease. Of 50 patients who had perennial chronic asthma, 41 obtained complete or nearly complete relief with the doses of prednisone that they were able to tolerate. Good or fair results were also obtained with the other types of allergic disease studied. The results were poor only in one case of seasonal allergic rhinitis.
Most of the patients obtained improvement from prednisone in doses about one-fifth those required with cortisone. Side-effects of prednisone included gastric complaints, euphoria, increased appetite, and overstimulation. None were serious. Edema was encountered in one patient, rounding of the face in six, and urinary frequency in seven. It appeared that prednisone is far less likely than cortisone to lead to fluid retention.
Feinberg AR, Feinberg SM. PREDNISONE IN ALLERGIC DISEASES. JAMA. 1956;160(4):264-266. doi:10.1001/jama.1956.02960390014004