• Electronic apparatus was developed to permit numerical scoring of the rigidity and tremor in 13 patients with paralysis agitans. It was then possible to compare the scores obtained during ethopropazine medication with scores obtained while the patients received a placebo. Ethopropazine caused a reduction of rigidity. Its effect on tremor was less consistent, but improvement was found in 9 of the 13 patients. There was no apparent correlation between changes in tremor and in rigidity. Replacement of the drug by a placebo caused, in one case, an increase in rigidity that became incapacitating within 24 hours; in other cases, the rigidity increased more gradually over a period from 3 to 10 days.
Agate FJ, Doshay LJ, Curtis FK. QUANTITATIVE MEASUREMENT OF THERAPY IN PARALYSIS AGITANS. JAMA. 1956;160(5):352-354. doi:10.1001/jama.1956.02960400010003