• Sodium acetrizoate (Urokon sodium) and diatrizoate sodium (Hypaque) have certain advantages over barium sulfate as contrast mediums in gastrointestinal roentgenoscopy. They yield true solutions in water, are miscible with intestinal contents and with blood, are not significantly absorbed from the stomach or intestine, and are relatively nontoxic.
Their low viscosity makes them relatively useful in the detection of small lesions and permits them to enter narrow fistulous passages. These advantages offset the disadvantages of high cost and bitter taste.
Davis LA, Huang K, Pirkey EL. WATER-SOLUBLE, NONABSORBABLE RADIOPAQUE MEDIUMS IN GASTROINTESTINAL EXAMINATION. JAMA. 1956;160(5):373-375. doi:10.1001/jama.1956.02960400031008