• Patients with systemic lupus erythematosus may suffer involvement of any part of the nervous system. It is a disseminated disease accompanied by severe manifestations of neurological and psychiatric dysfunction. This is shown by analysis of 100 clinically diagnosed cases. The neurological and the psychiatric types of manifestation can occur either alone or in combination and are of the utmost diversity. In their early stages they are liable to be misinterpreted, may lead to mistaken diagnoses, or may be falsely ascribed to cortisone therapy. The explanation probably lies in vascular changes in the blood vessels of the nervous structures.
Clark EC, Bailey AA. NEUROLOGICAL AND PSYCHIATRIC SIGNS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS. JAMA. 1956;160(6):455-457. doi:10.1001/jama.1956.02960410031007