• Zoxazolamine prevents or relieves spasm in voluntary muscles by depressing the central nervous pathways involved. It was administered by mouth to 100 rheumatic patients in whom the muscular stiffness and soreness made it impossible to carry out the necessary program of exercise.
Relief of the stiffness and aching was often complete within 30 minutes after ingesting the prescribed dose. Excellent or good results were obtained in 85 patients. Toxic reactions made discontinuance of this therapy necessary in 13 cases. Three especially successful cases are described.
Smith RT, Kron KM, Peak WP, Hermann IF. ZOXAZOLAMINE (FLEXIN) IN RHEUMATIC DISEASESPRELIMINARY REPORT. JAMA. 1956;160(9):745–748. doi:10.1001/jama.1956.02960440017005