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March 3, 1956


JAMA. 1956;160(9):764-768. doi:10.1001/jama.1956.02960440036010


REPORT OF TWO CASES  Col. Robert S. Nelson (MC), U. S. ArmyOf the numerous arsenical compounds used in treating disease, the amebacides are usually conceded to be the least toxic, and carbarsone (p-carbamidobenzinearsonic acid) is conceded to be the most innocuous of the arsenical amebacides. Large quantities of this preparation, alone or in combination with other agents, have been used in the past few years with surprisingly few reported instances of toxic effect. Most authors caution that it should not be used in cases where there is evidence of liver disease, but other contraindications seem to be lacking. Reactions reported during or after its use have usually taken the form of skin reactions, gastrointestinal upsets, neuritis, or kidney damage,1 but five instances of hepatitis have been described, one of which proved to be fatal.2 In this case, reported by Epstein2a in

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