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This is a useful handbook of the modern drugs used to allay pain. It includes a discussion of the salicylates and related compounds and the local anesthetics in current use. Indications and contraindications for the latter are given, and the untoward responses to local anesthetics are discussed. All physicians using these agents should be aware of their potential danger. The possibility of hypotension, convulsions, and laryngeal spasm must be prepared for before a local anesthetic is given. The authors carefully point this out and indicate the control measures and minimal emergency equipment that should always be available to the physician using these agents. This monograph is mainly devoted to the use of the opium derivatives and their synthetic substitutes. A strong plea is made for their intelligent use as pain killers, and care is taken to point out the considerations that must be understood if the danger of addiction is
Clinical Analgetics. JAMA. 1956;160(9):815. doi:10.1001/jama.1956.02960440087033