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Article
March 17, 1956

PHENOXYMETHYL PENICILLIN (PENICILLIN V) THERAPY OF SUBACUTE BACTERIAL ENDOCARDITIS

Author Affiliations

Detroit

From the Division of Infectious Diseases (Drs. Quinn, Colville, and Cox) and Department of Laboratories (Dr. Truant), the Henry Ford Hospital.

JAMA. 1956;160(11):931-936. doi:10.1001/jama.1956.02960460009003
Abstract

• Penicillin V was compared with penicillin G as to the concentrations attained in the blood when the two antibiotics were taken by mouth. In eight normal fasting subjects the average serum concentrations showed that penicillin G was absorbed faster and reached a higher concentration during the first half-hour, but thereafter penicillin V reached concentrations 1.7 to 2.8 times as high as those of penicillin G, and this difference was found consistently at the end of the first, second, third, and fourth hours. Penicillin V also gave higher blood concentrations than did penicillin G when given to four patients orally at four-hour intervals over a period of weeks.

Case histories of two patients with bacteremia caused by alpha-hemolytic streptococci Illustrated the effectiveness of orally administered penicillin V in bringing about a sustained clinical remission. A third patient, whose bacteremia was caused by Neisseria sicca, obtained clinical and bacteriological remission from a course consisting of 2 million units of penicillin V orally every four hours with 0.5 gm. each of streptomycin and dihydrostreptomycin intramuscularly twice daily. In a fourth patient, bacteremia caused by a Micrococcus pyogenes was halted but temporarily, and at the time of relapse the organism was found exceptionally resistant to antibiotics.

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