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April 7, 1956


Author Affiliations

Los Angeles

JAMA. 1956;160(14):1221-1223. doi:10.1001/jama.1956.02960490035010

Nitrofurantoin (Furadantin) has been found to be an effective bactricide both in vitro and in vivo. This paper reports on its use in the treatment of 112 cases of acute, persistent, or relapsing infections, the majority of which were found to be resistant to other chemotherapeutic agents and antibiotics.

Material and Methods

All the patients in this study were ambulatory and from private practice. A total of 112 patients was studied, but 5 are usually deleted in the following discussion because of inadequate follow-up. The patients' ages ranged from 3 to 87 years; 41 were males and 66 females. Any infection of less than three months' duration was classed as acute. There were 73 chronic and 34 acute cases. In all instances the patients considered as having chronic conditions had previously been treated with one of the sulfonamides and one or more of the most common antibiotics, alone or in

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