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August 3, 1940

ACUTE THROMBOPENIC PURPURA TREATED SUCCESSFULLY WITH SOLUTION OF PARATHYROID

JAMA. 1940;115(5):360-362. doi:10.1001/jama.1940.72810310001007
Abstract

Thrombopenic purpura has been treated by a variety of agents, without consistent results. Blood transfusion and splenectomy1 are the most favored procedures; other measures used include the administration of moccasin snake venom,2 ascorbic acid, calcium, liver extract and occasionally other substances.3 In the case reported here all measures, including splenectomy, failed to alter the course of the disease; a spectacular remission followed administration of solution of parathyroid.

REVIEW OF REPORTED CASES  The literature contains detailed reports of five cases treated with large doses of solution of parathyroid in which there were four recoveries and one death.In 1932 Lowenburg and Ginsburg4 reported the first case. A white boy aged 5 with purpura haemorrhagica was accidentally given large doses of solution of parathyroid. A total of 600 units was given in six days. Marked hypercalcemia developed, the serum calcium rising to a level of 19.6 mg. per

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